While on vacation in California Jeanette made a screen test and landed a bit role in the film Young April. For a brief time she used the stage name "Jan Lov".Cecil B. Demille offered her a contract and she quickly became one of Hollywood busiest starlets. In 1928 she had featured roles in Annapolis, Love Over Night, and Hold 'Em Yale. After her parents divorced Jeanette's mother and sisters came to live with her in California. She divorced her husband Harry in 1929. Jeanette claimed that he got jealous when he saw her onscreen. In 1930 she was engaged to song writer Walter O'Keefe but they broke up over their religious differences.
She retired from acting and married liquor salesman Bert E. Friedlob in 1936. The couple had a tumultuous relationship and broke up several times. Jeanette began suffering from a stomach ailment and was often ill. Despite her problems she told friends that she was happy and didn't miss being an actress. On August 4, 1942 Jeanette died from ammonia poisoning. Three days earlier she had swallowed a bottle ammonia at her home. It is unclear whether her death was an accident or a suicide. Jeanette was only thirty-five years old. She was buried at Forest Lawn Memorial Park in Glendale, California. Jeanette was a lovely and talented actress but her career and life were cut tragically short.